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AlphaDay-DS Tablets

Alpha Ketoanalogues & Essential Amino Acids — Double Strength

Manufactured & Marketed by: INTRA LIFE

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AlphaDay-DS

Brand: AlphaDay-DS
Strength: Double Strength (DS)
Dosage Form: Film-coated tablet
Pack Size: 10 × 10 Tablets (Alu-Alu blister)
Category: Nephrology / Nutritional
Schedule: Rx (Prescription only)
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BRAND OVERVIEW

AlphaDay-DS is a double-strength, fixed-dose oral combination of five calcium salts of α-ketoanalogues / α-hydroxyanalogue and five essential amino acids (in free or salt form) developed for the dietary management of patients with Chronic Kidney Disease (CKD). Each film-coated tablet supplies the full complement of essential amino acid equivalents required by uraemic patients while contributing minimal nitrogenous load to the renal system.

The "DS" (Double Strength) formulation roughly doubles the per-tablet content of conventional alpha-ketoanalogue tablets, allowing fewer tablets per dose, improving patient compliance — a key concern in long-term CKD therapy where the conventional regimen often requires 9–12 tablets per day.

THERAPEUTIC INDICATION

PRIMARY INDICATION

Adjuvant nutritional therapy in adult patients with Chronic Kidney Disease (CKD) — Stages 3, 4 and 5 — receiving a low-protein diet (LPD: ~0.6 g/kg/day) or very-low-protein diet (VLPD: ~0.3–0.4 g/kg/day) to delay progression of renal failure and postpone the initiation of dialysis.

Additional indications: Diabetic nephropathy · Pre-dialysis CKD · Maintenance haemodialysis · Peritoneal dialysis · Protein-energy wasting in renal failure · Hyperphosphatemia management.

MECHANISM OF ACTION

AlphaDay-DS works on the principle of nitrogen sparing through transamination. The calcium salts of branched-chain α-ketoanalogues (and the α-hydroxyanalogue of methionine) are nitrogen-free skeletons of essential amino acids. After oral absorption, they undergo transamination in the liver and skeletal muscle:

  • Renal haemodynamics: Unlike high-protein loading, ketoanalogues do not induce glomerular hyperfiltration; they help maintain residual renal function and slow the rate of GFR decline.
  • Calcium phosphate binding: The calcium component binds dietary phosphate in the gut, providing an ancillary benefit in the management of CKD-related hyperphosphataemia and secondary hyperparathyroidism.
  • Protein synthesis support: The regenerated essential amino acids, together with the directly supplied lysine, threonine, tryptophan, histidine and tyrosine, are channelled into anabolism, preserving lean body mass on a low-protein diet.
  • Reduced uraemic load: Because the body re-uses its own nitrogen instead of producing new urea, blood urea, BUN and other uraemic toxins decline measurably.
  • Nitrogen scavenging: Endogenous waste nitrogen — mainly from the breakdown of non-essential amino acids and urea recycling — is captured to aminate the keto-skeletons, regenerating the corresponding essential amino acids (leucine, isoleucine, valine, phenylalanine, methionine).
Net clinical effect: when combined with a properly supervised LPD/VLPD, AlphaDay-DS slows progression of CKD by an estimated 30–50% versus standard care, delays the need for dialysis, mitigates protein-energy wasting and improves metabolic complications including proteinuria, calcium-phosphate dysregulation, and disturbances in lipid and carbohydrate metabolism.

COMPOSITION (PER FILM-COATED TABLET)

Ingredient Role Strength
Calcium-3-methyl-2-oxo-valerate α-ketoanalogue of Isoleucine 134 mg
Calcium-4-methyl-2-oxo-valerate α-ketoanalogue of Leucine 202 mg
Calcium-2-oxo-3-phenylpropionate α-ketoanalogue of Phenylalanine 136 mg
Calcium-3-methyl-2-oxo-butyrate α-ketoanalogue of Valine 172 mg
Calcium-DL-2-hydroxy-4-(methylthio)-butyrate α-hydroxyanalogue of Methionine 118 mg
L-Lysine Acetate Essential amino acid 210 mg
L-Threonine Essential amino acid 106 mg
L-Tryptophan Essential amino acid 46 mg
L-Histidine Essential amino acid 76 mg
L-Tyrosine Conditionally essential amino acid 60 mg
Total Nitrogen Content — 72 mg
Calcium Content — 2.50 mmol (0.10 g)
Note: Excipients include maize starch, povidone, talc, magnesium stearate, colloidal silica, croscarmellose sodium, hypromellose, macrogol, titanium dioxide, and approved colorants (q.s.).

PACKAGING

  • Primary pack: 10 tablets in an Alu-Alu blister strip (moisture- and light-protective).
  • Secondary pack: 10 strips × 10 tablets per outer carton — total 100 tablets.
  • Storage: Store below 25 °C in a cool, dry place. Protect from light and moisture. Keep out of reach of children.
  • Shelf life: 24 months from the date of manufacture.

DOSAGE & ADMINISTRATION

Adults (≈70 kg body weight): The usual maintenance dose is 1 tablet of AlphaDay-DS per 10 kg body weight per day, administered in 3 divided doses with main meals — typically 4 to 8 tablets per day depending on the patient's weight, GFR and dietary protein restriction. Tablets must be swallowed whole with sufficient liquid; do NOT crush, chew or break.

Initiation criterion: GFR < 25 mL/min, on a controlled LPD (≈0.6 g/kg/day) or VLPD (≈0.3–0.4 g/kg/day). Treatment is generally long-term and individualised by the treating nephrologist.

ALTERNATIVE BRANDS AVAILABLE ON TATA 1MG & SIMILAR PHARMACIES

The following brands contain alpha-ketoanalogues with essential amino acids in comparable formulations. They are clinically interchangeable but composition strengths and excipient profiles vary; substitution should be at the discretion of the prescribing nephrologist.

# Brand Name Manufacturer Pack Approx. MRP (₹)
1 Ketosteril Fresenius Kabi India 100 tablets ₹ 3,790
2 Nefrosave Keto Sun Pharma / Lupin 15 tablets ₹ 420 – 450
3 Ketoadd Zuventus Healthcare 15 tablets ₹ 395 – 425
4 Aplazar Alniche Life Sciences 10 tablets ₹ 220 – 350
5 Renolog Eris Lifesciences 10 tablets ₹ 380 – 420
6 Ketoknol DS Knoll Healthcare 10 tablets ₹ 450 – 520
7 Alpha-KT Alkem Laboratories 10 tablets ₹ 380 – 410
8 Ketoalfa-DS Sun Pharma 10 tablets ₹ 475 – 525
9 Alpha KD-DS Alkem Laboratories 10 tablets ₹ 420 – 480

* Note: Prices are indicative MRPs aggregated from public listings on Tata 1mg, PharmEasy, Apollo Pharmacy and Truemeds (April 2026). Actual retail prices vary by region, batch and online discounts. Ketosteril (Fresenius Kabi) is the originator molecule and the global reference standard but is the most expensive option; Indian PCD/branded equivalents typically offer 60–85% lower per-tablet cost.