INTRABON

Composition:
Bosentan 62.5mg

Indication:
Pulmonary arterial hypertension

Packing:
10x1x10

Pack Type:
Tab

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INTRABON Tablets – Advanced Therapy for Pulmonary Arterial Hypertension (PAH)

INTRABON Tablets contain Bosentan 62.5 mg, a powerful dual endothelin receptor antagonist indicated for the treatment of Pulmonary Arterial Hypertension (PAH). Pulmonary arterial hypertension is a serious, progressive condition characterized by elevated blood pressure in the arteries supplying the lungs, leading to symptoms such as shortness of breath, fatigue, dizziness, chest pain, and progressive right-sided heart strain.

Bosentan works by blocking the effects of endothelin-1, a potent vasoconstrictor responsible for narrowing blood vessels in the lungs and causing pulmonary vascular remodeling. By relaxing pulmonary blood vessels and reducing pulmonary vascular resistance, INTRABON helps improve blood flow through the lungs, reduces the workload on the heart, and enhances exercise capacity in PAH patients.

Quick Product Information

What is INTRABON Tablets?

INTRABON contains Bosentan 62.5 mg, the first-in-class dual endothelin receptor antagonist approved globally for PAH management. Bosentan is recognized by the US-FDA, EMA, MHRA, and CDSCO (India) as a foundational therapy for adult and pediatric patients with WHO functional class II–IV pulmonary arterial hypertension.

By blocking both ET-A and ET-B receptors, Bosentan delivers comprehensive vasodilation in the pulmonary arterial bed, slows pulmonary vascular remodeling, and supports right ventricular function — making INTRABON a critical therapy for cardiology, pulmonology, and rheumatology specialists managing PAH and PAH associated with connective tissue disorders such as scleroderma.

Mechanism of Action

Bosentan is a dual endothelin receptor antagonist that blocks both endothelin-A (ETA) and endothelin-B (ETB) receptors. Endothelin-1 (ET-1) is known to cause vasoconstriction and promote vascular remodeling in pulmonary arteries, and its levels are significantly elevated in patients with PAH.

By blocking these receptors, Bosentan:

• Relaxes and dilates pulmonary blood vessels
• Reduces pulmonary vascular resistance (PVR)
• Improves blood flow through the lungs
• Decreases strain on the right side of the heart
• Slows pulmonary vascular remodeling
• Enhances exercise capacity (6-minute walk distance)
• Improves WHO functional class status
• Delays clinical worsening of PAH

Therapeutic Indications

INTRABON Tablets are indicated for:

• Pulmonary Arterial Hypertension (PAH) – WHO Group 1, functional class II to IV
• Improvement of exercise capacity and 6-minute walk distance in PAH patients
• Reduction of pulmonary vascular resistance and pulmonary artery pressure
• Management of symptoms (breathlessness, fatigue) associated with elevated pulmonary artery pressure
• Idiopathic PAH and PAH associated with connective tissue disease (e.g., scleroderma)
• PAH associated with congenital heart disease (Eisenmenger syndrome)
• Reduction of digital ulcers in adult patients with systemic sclerosis
• Pediatric PAH (age ≥ 1 year, under specialist supervision)

Clinical Advantages & Key Benefits of INTRABON

Dosage and Administration

INTRABON should be taken exactly as prescribed by a registered medical practitioner — usually a cardiologist, pulmonologist, or PAH specialist.

Safety & Precautions

• Liver function tests (LFTs) must be done before starting therapy and monthly thereafter — Bosentan can elevate liver enzymes.
• Hemoglobin levels should be monitored — risk of anemia.
• Pregnancy: Strictly contraindicated (Pregnancy Category X) — high risk of fetal harm. Effective contraception is mandatory during therapy and for 1 month after stopping.
• Hormonal contraceptives (pills, patches) may not be reliable with Bosentan — use additional barrier contraception.
• Breastfeeding: Not recommended.
• Use cautiously in patients with moderate hepatic impairment; contraindicated in severe liver disease.
• Monitor patients with low blood pressure or fluid retention / edema.
• Inform physician about all current medications to avoid significant drug interactions.
• Regular cardiology and pulmonology follow-up is essential during therapy.
• Caution while driving or operating machinery if dizziness occurs.

Contraindications – Who Should Not Take INTRABON?

• Pregnancy and women of childbearing potential not using reliable contraception
• Severe hepatic impairment (Child-Pugh class B or C) or baseline liver enzymes >3x upper limit
• Concomitant use with cyclosporine A — strictly contraindicated
• Concomitant use with glyburide (glibenclamide) — risk of severe hepatotoxicity
• Known hypersensitivity to Bosentan or any tablet excipient
• Breastfeeding mothers

Possible Side Effects

INTRABON is generally well tolerated, but some patients may experience side effects. Most are mild and manageable with monitoring.

Important Drug Interactions

Bosentan is metabolized by CYP3A4 and CYP2C9 enzymes. Inform your physician about all medicines you are taking. Significant interactions include:

• Cyclosporine A – strictly contraindicated
• Glyburide (glibenclamide) – risk of liver injury, contraindicated
• Hormonal contraceptives – effectiveness reduced; use additional contraception
• Warfarin – may decrease anticoagulant effect; monitor INR
• Statins (simvastatin, atorvastatin) – levels may decrease; monitor lipids
• Sildenafil / Tadalafil – often co-prescribed in PAH; dose adjustment may be needed
• Tacrolimus, Sirolimus – use with caution
• Ketoconazole, Itraconazole – may increase Bosentan levels
• Rifampicin – may decrease Bosentan effectiveness
• Clarithromycin – risk of hepatotoxicity

Storage Instructions

• Store in a cool, dry place below 25°C
• Protect from moisture and direct sunlight
• Keep tablets in original blister pack until use
• Keep out of reach of children and pets
• Do not use after the expiry date printed on the pack

Lifestyle & Supportive Care for PAH Patients

Comprehensive PAH management goes beyond medication. INTRABON works best when combined with the following supportive measures:

Top Bosentan 62.5 mg Brands in India – INTRABON vs Competitors

Bosentan 62.5 mg is marketed in India under various brand names by leading pharmaceutical companies. Below is a comprehensive comparison of INTRABON with the most popular Bosentan brands available across Indian retail pharmacies, online marketplaces, and B2B platforms. Because Bosentan is a high-cost specialty molecule used for a serious chronic disease (PAH), brand selection significantly impacts long-term affordability for patients and families.

*Prices are approximate MRP figures sourced from public marketplaces (Tata 1mg, PharmEasy, Apollo Pharmacy, IndiaMART, TradeIndia) and may vary by retailer, region, and discount offers. Always verify current pricing at your pharmacy or online portal.

Why INTRABON is the Preferred Choice

Where to Buy INTRABON / Bosentan 62.5 mg in India – Complete Marketplace Guide

Bosentan is a high-value specialty PAH medication available across India through every major distribution channel. Whether you are a patient refilling a prescription, a hospital sourcing for cardiology/pulmonology departments, or a distributor exploring franchise opportunities — here are all the platforms where INTRABON and similar Bosentan brands are accessible:

🏥 Top Online Pharmacies in India (B2C)

🏭 B2B & Wholesale Marketplaces

🏛 Government & Generic Outlets

🩺 Hospital & Specialty Cardiac Chains

🏪 Direct from Intra Life

Frequently Asked Questions (FAQs)

About Intra Life – Trusted Indian Pharmaceutical Company

With over 44 years of legacy, 44 specialty divisions, and a portfolio of more than 3000+ products, Intra Life is one of India's most reputed PCD pharma franchise companies. Honored with the National Healthcare Excellence Award, recognized by Chief Ministers and Union Ministers, and endorsed by celebrities including Mr. Virender Sehwag, Mrs. Shilpa Shetty Kundra, Mr. Sonu Sood, Mr. Jackie Shroff, Mr. Harbhajan Singh and many more — Intra Life is committed to delivering quality medicines, including critical specialty therapies like INTRABON, at affordable prices to every corner of India.

Conclusion

INTRABON Tablets provide effective management of Pulmonary Arterial Hypertension through dual endothelin receptor blockade. By relaxing pulmonary blood vessels and improving blood circulation within the lungs, Bosentan helps reduce symptoms, improve exercise capacity, and support better cardiovascular function in patients suffering from PAH.

When used under specialist supervision as part of a comprehensive PAH care plan — including regular liver and hemoglobin monitoring, contraception counseling, lifestyle support, and combination therapy where indicated — INTRABON can make a meaningful difference in the lives of PAH patients across India.

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